Altogether, the available evidence suggests that the psychedelic experience precludes sleep at the behavioural level yet allows the brain to continue cycling across waking-like and sleep-like electrophysiological states. Another study showed a decrease in latency between the bouts of REM sleep after dosing, with a decrease in theta activity78. We found a significant decrease of hippocampal theta power in a dose–response manner that could not be explained by changes in animal speed. Percentage of state duration (left panel) and mean speed (right panel) of each sleep-waking state for saline and different doses of 5-MeO-DMT experiments (ANOVA, #p

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