I also talk about the importance of the energetic preparation and how to integrate emotional and psychological content as you get ready for this transformative experience. This episode is packed with updates, insights, and personal reflections on my journey, and I’m excited to share everything I’ve been learning with you. That said, I’m back some updates, and in this episode, I answer several listener questions on topics like personal growth, wellness, Iboga preparation, and my business venture

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The animals were implanted with cannulae, and 500 nL of 5-MeO-DMT (4.3 mg/mL) was infused in the primary somatosensory cortex (Supplementary Fig. 6), as has been done in an earlier study with a dose of 5-HT2A/2c agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) that induced head twitches50. The injection of 5-MeO-DMT led to a marked increase ( + 75%) in pupil size lasting for 10–15 minutes (Fig. 4f; Supplementary Movie 7), which correlated with the increase in frontal SWA and decrease in occipital theta-power (Fig. 4g-i). To this end, we kept a group of animals awake for four hours, followed by an injection of the same dose of 5-MeO DMT as used before32,39,40,41. We hypothesised that if slow waves after 5-MeO-DMT were reflecting increased sleep drive, they would be enhanced when the animals are experiencing high sleep pressure. Therefore, next we addressed the effects of sleep deprivation on 5-MeO-DMT-generated slow waves. Distribution of the amplitude (f) and duration (g) of LFP slow waves during NREM sleep and during waking after the injection of vehicle or 5-MeO-DMT.
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Regarding PCL-5 factors, she scored the highest on ‘altered reactivity’ (4.00 ± 0.00), followed by ‘thought intrusion’ (3.80 ± 0.45), ‘negative mood and cognitions’ (3.71 ± 0.49), and ‘stimuli avoidance’ (3.50 ± 0.71


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According to the senior source, they avoided using the term psychedelic itself, instead calling 5-MeO-DMT a "central nervous system neuromodulator." But more than this, GH appeared to have an antipathy for psychedelic cultur

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